Intersurf options are all accessible in the main windows:

Extract an interface

Define groups of atoms by their molecule ids and a "VMD selection". Then just press "Extract interface surface". Using "all" as selection will give an interface between the two molecules (A and B), and using the same molecule id with differant selection ("resid < 5" and "resid > 4" for example) will give an interface inside the molecule.

Changing rendering options

Graphic options affects the current interface choosed in "Change current rendering mode" and the next interfaces to be created. If "auto_update" is activated the modified settings directly affects the surface (expet for "distance threshold") else, the "Update rendering mode" button must be pushed.